CANMRDG Program
2009 Meeting
Saturday, November 7, 2009
Baxter International Inc., Deerfield, IL
http://www.chem.purdue.edu/canmrdg/

Dear NMR Colleagues,

This year’s final program for the CANMRDG on November 7 at the Baxter Campus in Deerfield Illinois is now posted on our website http://www.chem.purdue.edu/canmrdg/.
The meeting will be held in the Conference Center and begins at 8:15 am (The first Saturday on Central Standard Time!). Please note that prior Registration is required to enter the Baxter Campus. Directions, parking and hotel information are available as links on the website.

Once again we are delighted to welcome two outstanding NMR scientists as our keynote speakers:- Professor Cindy Larive (University of California Riverside) and Professor Jim Prestegard (University of Georgia; Director of the Complex Carbohydrate Research Center). In addition, we have had an overwhelming number of papers submitted by our community and this has produced a very full program – please note we will start at 8:15 and run until 5:30 with cooperation from the speakers.

Please thank our faithful sponsors for their continued support for the meeting – Bruker, Cambridge Isotopes Lab, ISOTEC-Sigma-Aldrich, Protasis, and Varian. Links to our sponsors’ web-sites are found on our home page. Without their support we could not hear from our fine keynote speakers.
A very special thank-you is also due to Joe Ray and Christina Szabo and the staff at Baxter for all their support and efforts in arranging the meeting details, and finding speakers. They have done a superb job.
Your attention is called to the following items so that the meeting can run smoothly.

1.Registration: The registration form on the web MUST be completed by Friday, October 30. for admission to the Baxter site. Their Security Guards require a list of attendees in advance. It will also assist the folks at Baxter to plan the meeting space and breaks.

2.Lunch: We will have a buffet style lunch on the Baxter site this year. The price is $20 per person. A special discount rate of $10 per person is available for students courtesy of a generous donation by a sponsor. Advance registration for lunch is essential for catering purposes. Please click the “Yes” button on the registration form on our website by Noon Friday, October 30 to guarantee your lunch. The lunch list will be updated each day on the CANMRDG web site between 4:30 and 5:00pm so you can check your lunch status. No registration means no food! Once again no shows will be requested to pay for unused meals.

3.Maps, Lodging & Parking Information: These can be found under the links on the web-site http://www.chem.purdue.edu/canmrdg/.

I look forward to seeing you on November 7. Don’t forget to register on the web by Oct 30
Any questions or comments, please feel free to contact me by email at grutzner@purdue.edu or call 765-494-5247 (afternoons).
Last-minute details and information regarding the Baxter site can be provided by Christina Szabo, christina_szabo@baxter.com.

Yours resonantly,
John B. Grutzner

Meeting Program

Chair: John Grutzner (Purdue University)
8:15 ‐ 8:30 Welcome: Norbert Riedel (Chief Scientific Officer, Baxter)
8:30 ‐ 8:50 Progress Toward Automatic Structure Verification Assisted by
Connectivity in Dual Microcoil NMR Ke Ruan (Pfizer Inc.)
8:50 ‐ 9:10 rNMR - Open Source Software for NMR Data Analysis
Seth Schommer (University of Wisconsin Madison)
9:10 ‐ 9:30 Universal Quantitations by NMR: Solvent Concentration Reference
and Receiving Efficiency Hauping Mo (Purdue University)
9:30 ‐ 9:50 Photodimerization of A-Trans-Cinnamic Acid: Domain Sizes in Irradiated
Single Crystals Sarah Mattler (Washington University St. Louis)
9:50 ‐ 10:05 Contribution of Long-Range Interactions to the Secondary Structure
of an Unfolded Globin Daria Fedyukina (University of Wisconsin Madison)
10:05 Coffee
Chair: Christina Szabo (Baxter)
10:30 ‐ 10:50 The Use of In Vitro Chemoselective Isotopic Tagging to Enhance
NMR-Based Metabolic Profiling Tao Ye (Purdue University)
10:50 ‐ 11:10 Global Metabolomics of Breast Cancer Cells Quincy Teng (US EPA)
11:10 ‐ 12:10 Keynote Lecture: Adventures in Mixture Analysis by NMR
Cynthia Larive (University of California Riverside)
12:15 Lunch
Chair: Joe Ray (Baxter)
1:30 ‐ 1:50 Enhancing NMR's Sensitivity by Photochemically-Enhanced Dynamic
Nuclear Polarization Silvia Cavagnero (University of Wisconsin Madison)
1:50 ‐ 2:10 NMR Studies of Substrate Conformation Upon Binding the Hsp70
Chaperone Protein Nese Kurt Yilmaz (University of Wisconsin Madison)
2:10 ‐ 3:10 Keynote Lecture: New Assignment Strategies for Large and Glycosylated
Proteins James H. Prestegard (University of Georgia)
3:10 Coffee
Chair: John Grutzner (Purdue University)
3:30 ‐ 3:50 Chemical Shift Perturbations Reveal Disrupted "Hot Spot" Binding in the
Src SH2 Domain Joshua Ward (Purdue University)
3:50 ‐ 4:10 Application of REDOR SSNMR to Understand Early Steps in HIV Infection
Kelly Sackett (Michigan State University)
4:10 ‐ 4:30 Cu2+ Binding Studies to Alzheimer s B Amyloid Fibrils by Solid state
Alzheimer’s B-Amyloid Solid-state
NMR Sudhakar Parthasarathy (University of Illinois Chicago)
4:30 ‐ 4:50 Magic-Angle Spinning Solid-state NMR Studies of a 41 kDa DsbA-DsbB
Membrane Protein Complex Lindsay Sperling (University of Illinois Urbana-
Champaign)
4:50 ‐ 5:10 Proton Detection Methods for Rapid Structural Analysis of Membrane
Proteins and Fibrils Chad Nieuwkoop (University of Illinois Urbana-
Champaign)
5:10 ‐ 5:30 Chemical Shift Assignments of Alpha-Synuclein Fibrils
Gemma Comellas (University of Illinois Urbana-Champaign)